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The most striking duplication in SOPE is 13,476 bases in length and encompasses the genes encoding the molecular chaperone GroEL and its cochaperone GroES as well as the adjacent genes yjdC, dipZ, cutA, aspA, fxsA, yjeI, yjeK, and efp.
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The enrichment of Alu repetitive elements is most striking around the centromeric duplication junctions and this increased frequency is likely a consequence of an enrichment of Alu sequences in the centromeric part of the genomic region surrounding the LMNB1 gene.
An analysis of the genomic architecture surrounding the breakpoint junctions suggests a number of features that may predispose the region to genomic instability leading to the LMNB1 duplication; the most striking of which is the involvement of Alu repetitive elements at the duplication breakpoints.
Of the loci where previous evidence was modest, the most striking result was for AS/PWS duplications, where we found eight in patients and none in controls (P = 0.0055).
Our analysis of the mutational distance between duplicate pairs (Ks) across the teleost species, however, produced the most striking illustration of different patterns of duplication and retention.
The most striking pattern seems to be that most developmentally regulated genes are result of lineage-specific duplications.
The most striking statistic relates to demographics.
What were the most striking differences?
The simplest sculpture is the most striking.
The most striking materials used are feathers.
The effect is most striking live.
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