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Current approaches to identifying causal variants by patient sequencing, including ours, can reliably interpret only the most straightforward subset of the variome (nonsense, missense, and splice-site variants).
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We estimated and compared three models: Model 1 used all available predictors; Model 2 focused on a subset of predictors that tend to be the most straightforward for regulators to obtain from routine operational data; and Model 3 had only one predictor, the variable most strongly associated with the outcome.
But the simple observation that all mitochondrial genes are still a subset of the Reclinomonas gene set indicates in the most straightforward manner that mitochondria have gone genome reduction in evolution, not gene acquisition.
From a practical perspective the most straightforward approach would be to use sequential rounds of positive selection to isolate individual cell subsets.
Although the most straightforward explanation would be an imperfect transmission of the bacterium towards offspring, PCR screening demonstrated for a subset of the data that infected females (n = 4) only produced infected offspring (n = 47), indicating very high transmission efficiencies.
The first and most straightforward is geographic.
Anniversaries provide the most straightforward narrative peg.
This is the most straightforward approach.
That's the most straightforward one.
Northwest is among the most straightforward.
"He's probably the most straightforward C.E.O.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com