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Exact(6)
The mechanism with the most statistical support is thus consistent with aspects from all existing proposals in the literature.
As now described in the manuscript, in all cases, our results held: the BDP model experienced the most statistical support.
(A ) There is most statistical support for a bottlenecking mechanism whereby mtDNA dynamics is stochastic within a cell cycle, involving random replication and degradation of mtDNA, and mtDNAs are binomially partitioned at cell divisions.
Using approximate Bayesian computation and mouse data, we find most statistical support for a combination of binomial partitioning of mtDNAs at cell divisions and random mtDNA turnover, meaning that the debated exact magnitude of mtDNA copy number depletion is flexible.
Although the conventional statistical significance testing procedures have successfully identified several susceptibility loci, it has become clear that many of the true disease associations may be much lower down on the ranked list of hits, compared to the top hits with the most statistical support [ 4, 17, 18].
We have thus obtained analytic solutions for the time behaviour of mtDNA copy number and heteroplasmy throughout the bottleneck with no assumptions of continuous population densities or fixed population size, under a physical model with the most statistical support given experimental data.
Similar(54)
At the same time, Stumpf and Porter [29] argue that "most reported power laws lack statistical support and mechanistic backing".
But also in this analysis, statistical support for most of the nodes is lacking.
Three major mtDNA clades containing Leucopternis species (figure 1) were recovered in all combined analysis, with high levels of statistical support in most cases.
Small sample size also decreases power, which at least partially explains the rather modest degree of statistical support for most of the reported FTO findings.
Virus-based clustering results display lower values of statistical support for most nodes, due in part to the lower number of viral hits.
Related(20)
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