Immunoaffinity (IA) depletion is currently the most specific method for performing this step.
Histopathology is the most specific method for diagnosing CMV, especially by detecting organ-specific manifestations related to CMV.
Therefore in the current study we used shRNA based knockdown of TP53 as the most specific method on otherwise genetically identical cell lines.
Isolation and culture of HCMV is the most specific method, but is time consuming and has low sensitivity.
Most importantly, measurement of concentration of serum TXB2 (a metabolite of TXA2 which is the direct product of COX-1) is the most specific method for the assessment of laboratory response to ASA therapy.
When calculating the POPR for the Sp at PCR Ct-value cut-off 37 against Sp of BC, it was found to be 0.305, i.e. in only 30% of the cases will the PCR assay be the most specific method.
According to Selbach's article DIANA-microT was found to be the most specific method (Maragkakis et al., 2009), with PicTar (Krek et al., 2005) and TargetScan (Lewis et al., 2005) close seconds.
Although genetic testing is the most specific method of diagnosing HCM, the diverse genetic heterogeneity of HCM and incomplete knowledge of all causal mutations lend poor sensitivity to this diagnostic tool.
Comparing annotation of each base in both sequences with the true repeat annotation sampled from the model (table columns repeat sensitivity and specificity), we note that the marginalized posterior decoding is the most sensitive, and the block decoding the most specific method.
On one hand, fungal neutropenic enterocolitis is probably underestimated, since histology, as the most specific diagnostic method, is rarely obtained in living patients.
