Furthermore we found that the most specific case definition, which restricted to specific bleed codes from both datasets, excluded severe cases and resulted in a lower 28 day case fatality.
Our findings suggest that where information is limited to symptoms (e.g. in a survey based on questionnaires), the most specific case definition would be numbness/tingling with an extensive median distribution, and also affecting part-median regions of the hand, but with no involvement of non-median regions.
Also of concern was the observation that associations with the most specific CTS case definition were not as strong as associations with the less specific CTS case definition.
The most specific, persuasive case I've seen for more Fed action comes from Joseph Gagnon, a former Fed staffer now at the Peterson Institute for International Economics.
Febrile upper respiratory tract illnesses occurring during the peak influenza period was identified as the most specific clinical case definition expected to have the highest positive predictive value for true influenza [ 18].
The response patterns were different indicating that the patient factors were most commonly selected as influencing general referral decisions, whereas tumour-related factors were most commonly selected for specific cases.
This framework allows for a better integration of material processing at the optimization stage, and recovers most standard setups as specific cases.
Cardiac birth defects were increased in both areas, with RRs increasing from the most general grouping (all cardiac defects, 5 cases in the PCE area, and 15 in the TCE area) to most specific (conotruncal defects, 1 case in the PCE area, and 3 in the TCE area).
From non-identical entries overlapping along protein sequence only the most specific was selected in case a parent-child relationship existed between them.
aPooled analysis performed by including results of single marker (either the most specific or the most sensitive in cases with equal specificity) in cases where multiple markers were assessed per study.
