Sentence examples for most specific annotation from inspiring English sources

Ideally, each protein should be annotated with a GO term on a leaf node, in other words, with the most specific annotation.

If a node has multiple Molecular Function annotations, the most specific annotation will determine the node color.

A fairly obvious action is to select the most specific annotation out of a set of hierarchically ordered GO terms (step 2 of the algorithm pseudocode).

On the other hand, the minimal term need not exist, so that the finest consistent term is higher in the hierarchy and represents the most specific annotation that can be assigned to U i as a whole.

In this way we put more emphasis on the most specific annotations, and two proteins annotated with the same more specific terms receive a similarity score larger than that obtained by two proteins annotated with less specific GO terms.

Blast2GO assigns GO annotations to the query sequence by pooling the retrieved GO terms and determining the most specific annotations based on an annotation rule (AR).

If a gene product had multiple manual annotations in the same direct lineage of the ontology (i.e. in the same path leading up to the root of the ontology), the manual annotations were filtered in order to keep only the most specific annotations.

Ref. [15] also provides a study of the "GO correlation" (fraction of pairs of coexpressed genes sharing their most specific GO annotation) as a function of the cutoff in Pearson correlation coefficient used to define coexpression.

Thus, we obtain a set of gold standard negatives by finding pairs of proteins in which both members have annotations (other than "biological process unknown") but whose most specific co-annotation occurs in terms with more than 1000 total annotations (~25% of the annotated genome) and with one or fewer votes from our panel of six experts.

to assign the most specific GO annotations possible to the original query sequences.

These nodes contain the most specific and informative annotations that resulted significantly enriched.