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Telomerase is expressed in most types of tumors but not in most somatic cells.
This finding was somehow surprising considering that the ribosomal RNA represents the dominant type of RNA in cells and most somatic cells have abundant ribosomes.
Most somatic cells produce energy predominantly through oxidative phosphorylation, whereas cancer cells produce energy mainly through the less efficient glycolytic pathway, followed by lactic acid production under aerobic conditions (Warburg, 1956).
These studies demonstrated that most somatic cells can be reprogrammed with 4 or 3 factors (excluding c-Myc).
Thus, though nuclear at steady state in most somatic cells, TIAR exerts both nuclear and cytoplasmic functions.
During spermatogenesis, in contrast to what is observed in most somatic cells, a large quantity of mRNAs accumulated during transcription are stored as mRNPs, which are subsequently assembled into polysomes [31].
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In addition to gene dosage compensation between male and female cells by X chromosome inactivation in female cells [32], [33], the hemizygous condition of males regarding the X chromosome is compensated by a two-fold transcriptional upregulation of the mammalian X chromosome in most somatic cell types [9], [34], [35].
Histone H1.2 is a linker found in most somatic cell nuclei.
In humans, telomerase activity is detectable in germline cells and in certain stem cells, but not detectable in most somatic cell lineages (Harley et al, 1997).
Reprogramming incompletely occurs in most somatic cell nuclear transfer (SCNT) embryos, which results in misregulation of developmentally important genes and subsequent embryonic malfunction and lethality.
In most somatic cell types of metazoans, CIN is also expected to be low, although direct measurements have been more difficult.
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