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The two most soluble molecules, pteridine and antipyrine, are the two worst predicted according to both measures.
Most soluble molecules show an 'hour-glass' distribution, particularly within the patient group corresponding to groups of patients with higher and lower levels of analyte.
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Although most soluble CEA molecules are unable to mediate intercellular associations, C-CAM4 actively promotes cell adhesion (Lin et al. 1998).
The authors of that nomenclature currently prefer to use CVVH with pump-driven ultrafiltrate control because of its greater ability to remove middle molecules (most soluble mediators of sepsis are middle molecules), its safety, and ease of operation by nursing staff.
Despite the barrier, water, most lipid-soluble molecules, oxygen, and carbon dioxide can diffuse through it readily.
The intact BBB prevents diffusion of most water-soluble molecules above 500 Da [ 17].
Ultracentrifugation of the HA synthesis inducing media revealed that the HA inducing factor(s) was (were) to be found in the supernatant, thus most likely a soluble molecule.
Most conventional drugs are small water soluble molecules and many treatment regimes would benefit from the enhanced bioavailability and reduced dosing frequency that transdermal delivery offers.
Among various soluble molecules inducing the production of type I collagen, the most extensively studied is transforming growth factor-beta (TGF-β) [ 5, 6].
It was interesting to note that the aqueous solubility of the guest molecule appears to correlate with the aqueous dissolution rates of the corresponding cocrystal, with benzoic acid being the least soluble (0.34 g/100 g), fumaric acid being intermediate in solubility (0.61 g/100 g), and succinic acid being the most soluble (7.5 g/100 g).
Most of the studies in the past decade addressing these cellular interactions have focused on tumor cell-derived soluble molecules.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com