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Most single agent chemotherapeutics provide only low response rates.
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Cisplatin (DDP) was used in most single-agent chemotherapy regimens.
Cancer of the pancreas responds poorly to most single-agent or combination chemotherapy regimens.
Given that most single-agent therapies have limited activity in patients with malignant gliomas, we examined whether AdsTRAIL could exhibit enhanced antitumor activity in combination with agents currently in use or in trials against gliomas.
Objective response rates remain low with most single-agent chemotherapy including 21 26% with 5FU (Carter, 1975; Moertel, 1976), 26% with ifosfamide (Bernard et al, 1986), 22% with epirubicin (Wils et al, 1985) and 21% with cisplatin (Wils et al, 1993).
IFN-α is one of the most widely used first-line treatments and probably the most effective single agent in the treatment of CTCL.
Surprisingly, and in contrast to the observations made on OS cell lines, combination treatment of Ad5-Δ24RGD with doxorubicin or cisplatin did in most cases not result in a more pronounced cytotoxic effect compared to the most effective single agent treatment.
It is the most active single agent currently used for treating metastatic melanoma [4].
These in vitro experiments showed that paclitaxel was the most effective single agent across all cell lines.
Among these new agents, paclitaxel is the most active single agent in advanced urothelial cancer.
Dox is considered the most active single agent in breast cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com