The theory presented in this paper does contain a number of simplifying assumptions, most notably that exposure probability or diagnostic test sensitivity and specificity are independent of host genotype.
The principal limitations of most models are many simplifying assumptions about joint properties and structures that do not account for in-vivo symptoms and processes [ 39].
Our model makes a number of simplifying assumptions, most notably the independence of the right and left hemisphere basal ganglia motor loops.
Most studies are based on simplifying assumptions about the capabilities of power plants to operate at part load and to regenerate additional solvent after interim storage of solvent.
Since the original Ross Macdonald formulations of vector-borne disease transmission, there has been a broad proliferation of mathematical models of vector-borne disease, but many of these models retain most to all of the simplifying assumptions of the original formulations.
The standard way to deal with such complications in modeling evolution, as in most of science, is to make simplifying assumptions - such as that migration is symmetrical (immigration and emigration balance one another), that migration rates are low, or that migration is a deterministic (rather than a stochastic) process.
In the absence of explicit theory, most approaches continue to incorporate one or more simplifying assumptions to achieve numerical solutions.
Like most statistical models, our approach relies on some simplifying assumptions.
Every approach to incorporating spatial detail into stochastic biochemical simulations makes a different set of simplifying assumptions, which means that the most accurate approach may depend on the properties of the simulated model.
The most general (in the sense of making the fewest simplifying assumptions) mathematical description of evolution that we currently have, the Price equation [ 12], does not easily accommodate stochastic evolutionary processes.
