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Moreover, we included the analytical proposal and its comparative with the most similar protocols in the literature.
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The optimized glycine regimen for C. pasteurianum involves exposure of early exponential phase cells to 1.25% glycine for 2 3 hours, which is most similar to protocols developed for Mycobacterium avium[ 37], Bacillus subtilis[ 54], and B. thuringiensis[ 55].
2.EEUC-Q: EEUC is the most similar self-organized clustering protocol to our clustering algorithm.
Figure 5 shows that our protocol leads to the most similar groups in terms of size as well as expected behaviour change.
Further study should be performed in larger and more homogenous groups of patients (i.e., those treated with similar protocols and doses of the most nephrotoxic drugs).
As well as differences, there are some common elements to most standard and nonstandard treatment pathways such as similar protocols for diagnostic assessment and classification of tinnitus severity, as well as similar management options (Baguley et al. 2013).
The most similar scheme is energy efficient directional routing (EEDR) protocol which is proposed in Ref. [1].
Nonetheless, our protocol still results in the most similar group in terms of mean expected behaviour, regardless of the sample size considered.
Therefore, the harmonised protocol designed (see 'Materials and Methods, Harmonised in vitro stimulation') was most similar to that used by Centre D; however, some modifications to the protocol were incorporated for ease of multi-centre application.
The first mixed cohort was obtained from a multi-center study in which standardized imaging protocols were well controlled by selecting the most similar reconstruction kernels between vendors.
To compare the two HSQC matching protocols (NN and DGA) with MFP, the 44 most similar HSQC spectra for each method were considered.
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