Moreover, in the cross-platform comparisons we identified the GR as a significantly implicated transcription factor.
This mutation is significantly implicated in both sporadic and inherited human colorectal carcinogenesis [ 12- 14].
Five percent were down-regulated significantly, implicating their role in free-swimming, attack-phase physiology.
Our 346 candidate genes were most significantly enriched for genes implicated in T cell and B cell receptor signaling, GM-CSF signaling and IL-2 signaling (Table S3), which may have been expected since all tumors were of lymphoid origin.
The most significantly influenced pathway was that for the oxidative phosphorylation (Fig. S1) implicating that the primary responses to the excitoxic damage after KA-induced SE involves oxidative mechanisms.
The pathways most significantly targeted in men are related to type I interferon, which has previously been implicated in the sexual dimorphism in response to viral infections (drivers of COPD exacerbations) [ 36, 37] and in autoimmune diseases [ 38].
Most significantly, a vicious cycle involving obesity and taurine has recently been discovered [28], implicating low levels of taurine in the continuing maintenance of this condition.
Interestingly, another DEAD box related gene, DHX16, was the most significantly (q-value=1.5×10−5) over-expressed gene in cerebellum compared to other brain regions but it was not implicated in our GWAS analysis.
In addition, BCL10 was the eighth most significantly connected gene to our previously identified leprosy susceptibility genes based on the GRAIL analysis, indicating that there is a strong biological relationship between BCL10 and previously implicated susceptibility genes.
And perhaps, most significantly, different expectations.
