Most significantly, this effect of c-Met is independent of binding of HGF, suggesting that integrin-dependent trans-activation could be responsible for tumourigenesis.
Most significantly, the effects of GSK3 inhibitors in 2i conditions have recently been shown to be mediated principally through β-catenin (Wray et al., 2011).
In the mineral extraction industry, comminution modeling is not only interested in maximum rock strength, but also, or much more, in the energy required to induce rock fracture and, most significantly, into the effect of energy application on the produced rock fragments size distribution.
We hypothesized that Twsg1 −/− mice would be particularly sensitive to the subteratogenic effects of RA, the midface would be most significantly affected, and the effects of a combined treatment of P19 cells with BMP and RA would be mediated through upregulation of apoptosis.
The difference between the 99th and 90th percentiles of maximum temperature, that is the range over which the heat effect was estimated, was the most significantly related with the heat effect (p = 0.011), with larger risks for larger temperature differences.
Their voices--when raised in unison, with authority, and with fearlessness--can effect change most significantly.
Other authors highlight the importance of canopy-species leaf litter as a key factor influencing soil acidity and thereby nutrient stocks, whereas the upper 10 cm of soil are most significantly influenced by tree-species effects (Nordén 1994; Finzi et al. 1998; Augusto et al. 2002, 2003).
Most significantly, however, would be the deterrent effect by decimating the market for abusive tax avoidance schemes by changing the risk-reward ratio.
Among the variables, MgSO4 (X2), CaCl2 (X3), pH (X4), and fermentation time (X6) were the most significantly linear and had a positive effect on enzyme production.
Most significantly, our replicated patterns exhibit lotus effect (superhydrophobic surface with ultra-low contact angle hysteresis), that upon reduction of silver nanoparticles, exhibit superhydrophobicity with high contact angle hysteresis (rose petal effect).
