Most significantly, sperm bound to hyaluronan display a reduced frequency of chromosomal aneuploidies in comparison to their nonbinding counterparts (Kovanci et al., 2001; Jakab et al., 2005).
These files describe genomic regions significantly bound by most of the proteins assayed by modENCODE.
No DARPin significantly bound mRuby2.
In addition, ML171 did not significantly bind to a large battery of human or rodent G-protein coupled receptors (GPCR), channels and transporters expressed in the central nervous system, did not significantly bind most of the receptors tested in the binding assays with the exception of serotonin (5-HT2B and 5-HT2C), adrenergicrgic (alpha2C) receptors (% of inhibition >60%).
Most significantly, the engineered molecules bound specifically to pMHC on cells.
Most significantly, purified PR protein binds to trans-retinal and pumps out proton (Han S-I, Kwon S-K, Kim JF, and Jung K-H, unpublished data).
In contrast, cell cycle−related genes were not enriched in the set of genes bound solely by RBf2; instead, the most significantly enriched category was that of ribosomal proteins.
Most significantly, cytochrome c, once in the cytosol, binds to apoptosis protease-activating factor-1 (apaf-1) to recruit and activate initiator caspase 9. Once activated, caspase 9 activates executioner caspases and unleashes apoptosis.
Its molecular structure most significantly reveals a Zn– ortho(benzamide) bond [Zn1 C18 2.039 3) Å] replacing the tBu "bridge" in 2. The carbonyl (C= O) function of the deprotonated benzamide binds to lithium [Li1 O1 2.019(5) Å].
Although the most significantly enriched class of target genes encode transcription factors, we find that Ubx is bound to many genes that carry out a wide variety of functions.
