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The most significant window on MSP-Best analysis was at 1q23.2-q25.3 (p = 1.94E-03), jundernder LK-suggestive criteria, providing nominal evidence for linkage within the window.
The most significant window spanned all five SNPs giving a global p = 0.0005 (p = 0.0141, after the FDR correction).
For the combined p value, the most significant window lay within the 40 kb region (i.e. ±20 kb) surrounding the selected allele in 46% of the simulations, compared with 68% for the CLR (Fig. 2c).
The most significant window identified a large region located towards one end of chromosome 6, as observed previously in other population samples from Senegal, The Gambia, and Guinea [ 17, 22, 36], although the mechanism and target of selection remains unknown.
The most significant window ('window 81' containing rs313 A>G, rs314 A>G, rs77434393 G>A and rs316 C>A) was associated with both HDL-C (global P=2.32E-04) ApoA1poA1 (global P=0.021).
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Most significant windows were clustered together as extended chromosomal fragments resulting in 170 differentiated regions (supplementary table S1, Supplementary Material online).
The 6q21 region remains the most significant for window sizes of four and greater even when these top two SNPs are removed.
We therefore gradually raised the cutoff values to obtain the most significant (P<0.001) windows with extremely high FST in each population pair, and then assigned the empirical P-value to these windows.
Active Directory is regarded as one of the most significant change between Windows NT 4.0 and Windows 2000.
The effect of MSEL on increasing gene expression in MDAMB231 vs. HMEC was most significant when the window size between MSEL and nearby gene was 100 kb (Additional file 2: Table S6).
Microsoft has called Windows 8 the most significant redesign of the Windows interface since its groundbreaking Windows 95 OS.
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