Sentence examples for most significant upregulated from inspiring English sources
The most significant upregulated RA-inducible gene in CD34+ cells from CAD patients was RAI1, a transcription factor which does not posses a DNA binding domain but likely influences differentiation through complex formation with other proteins mediating chromatin remodeling [ 28].
One very intriguing gene (An07g03760) was upregulated on maltose with same level of significance and fold difference as the most significant upregulated secretory pathway genes.
A list of the most significant upregulated and downregulated mRNAs is shown in Supplementary Tables 1A and B. Among the genes whose mRNA expression was upregulated in GEF-R and ERL-R CALU-3, there were vimentin, caveolin, HIF-1α and VEGF-B, which are generally correlated to a more invasive cancer cell phenotype.
Enrichment analysis indicated that genes related to defense response and detoxification of xenotoxic compounds were the most significant upregulated gene groups.
The p53-regulated key regulator of apoptosis and cell cycle progression Cdkn1a (increased by approximately 22-fold as measured by Q-RT-PCR) is among the most significant upregulated transcripts in our data and is regulated post-translationally by Akt phosphorylation [44], [45].
P38 MAPK signaling was identified as the most significant upregulated pathway from this analysis; ERK/MAPK signaling was the second.
Furthermore, in a meta-analysis, YY1 was scored as the most significant gene upregulated in metastatic breast cancer [ 33].
The first-most significant upregulated gene cluster contained genes involved in cell projection and the formation of dendritic spines (CDC42, FBX02, EXOC4, RSHL3, TTLL9, and ATP1A2).
For example, A-FABP was one of the most significant markers differentially upregulated on cediranib addition to chemotherapy.
When compared to the dauer vs. dauer exit experiment, five out of the six biclusters that show most significant enrichment with genes upregulated in dauers vs. dauer exit worms, also show trends for higher expression in dauers vs. adult worms and late larvae (Additional file 2: Figure S1).
The genes that were upregulated in the most significant gene sets are described in Table 3.
