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On the other hand, according to the analysis of Figures 8.A C an anti-variation mechanism appears to protect the most significant tier of biological functions.
Due to wide evolutional (and structural) divergence, there is a "luxury" of inhibiting the most significant tier of functional elements in the prokaryotic cell with minimal risk to normal human tissues.
We have recently proposed a two-tier model of antimicrobial peptide resistance in B. cenocepacia [ 14] with the first and most significant tier consisting of the complete lipopolysaccharide (LPS) core oligosaccharide (OS) [ 9, 15] and the lipid A and core OS aminoarabinose residues that are essential for the viability of B. cenocepacia [ 16, 17].
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The most important tier is the flat-rate basic state pension (BSP).
Drew, whose brother J. D. Drew played for the Red Sox, joins Shane Victorino and Ryan Dempster — two other second-tier free agents — as Boston's most significant additions this off-season.
Some clues emerged as a large number of top-tier trainers convened here on Saturday for Imperial Cup day, possibly most significant among them the news that McCoy is expected to ride Uxizandre in the Ryanair Chase on Thursday.
The most significant: Maj.
Most significant, Paul started recruiting.
Most significant is the soil.
Take Bruges' most significant museums.
The most significant is price.
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