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By inspecting the network topology, we identified the most significant threshold that resulted in a network that was the most different from what was expected by chance.
PreRT PSA of 1 ng/ml was the most significant threshold that could distinguish patients with good or bad biochemical control after RT: PSA <1 ng/ml was associated with a 3-year bDFS of 68.3% compared to 30.1% for PSA ≥1 ng/ml (p = 0.0006).
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The areas (which are equivalent to proportions) under the curves in each state concurrently change in most significant manner when threshold was set to the intersection value.
The third section deals with the case of endocrine disrupters, where the most significant question regarding thresholds is the possible additivity to an endogenous background of hormonal activity.
The most significant pathway crosstalks (the threshold of P-value of significance test is set as 0.001 strictly) consist of the map of pathways.
The estimation of L is realized as described in section "Diagonal loading and estimation of L" (selection of the most significant eigenvalues with a threshold corresponding to 0.5% of the first eigenvalue) leading to L = 16.
For instance, as shown as Fig. 3I, the areas (equivalent to the proportion of mitochondria in each state) under the curves in the DP or AR state concurrently changed in a most significant manner only when threshold was set to 0.05 μm/s.
But, as the Washington Post put it, the changes were "the most significant since the filibuster threshold was lowered in 1975 from a two-thirds majority to 60 votes".
For each BES we recorded the pseudochromosome coordinates of the most significant alignment above a threshold E-value of 10-30.
For each predicted cluster, we identify a known complex with which the intersection is the most significant according to a threshold value of ρ .
Although none of our markers showed significance at this threshold, the most significant result (rs723149; 67.7 cM; P-values 5.5 x10-5 and 2 × 10-4 for PMD and DA, respectively) occurred on chromosome 7 near our linkage peak.
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