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No-one can be left in any doubt that the MB was the Mubarak regime's most significant target.
The six most significant target genes connected to the differentially expressed swine miRNAs (BMI1, GBX2, OTX2, SOX4, ZNF423, NKX6-1) play a role in nervous system development and function (Figure 2).
Since members of the Myc transcription factor family are largely interchangeable [45], and n-Myc constitutes the major isoform of the Myc family in brain, one may propose that Txnrd1 is one of the most significant target genes of n-Myc in brain.
DNA is the most significant target of radiation exposure for survival and carcinogenesis.
This hypothesis is supported by the known functions of the most significant target gene, Angptl4, which responds to lipid metabolism and energy homeostasis, and participates in angiogenesis (Koster et al., 2005; Scott et al., 2012).
Although the density of spore production around the muzzle is the most dramatic sign of infection, the skin of hibernating bat wings is the most significant target of G. destructans [ 7].
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Delta-turbidite systems represent one of most significant targets for hydrocarbon exploration and development.
Succinate ubiquinone oxidoreductase (SQR, EC 1.3.5.1, complex II), an essential component of cellular respiratory chain and tricarboxylic acid (or Krebs) cycle, has been identified as one of the most significant targets for pharmaceutical and agrochemical.
One of the richest and most significant targets was the "China Fleet", an annual convoy of East Indiamen from China and other Far Eastern ports that carried millions of pounds worth of trade goods.
The most significant targets genes were identified by miRanda [29] and verified by TargetScan [30] and PITA [31].
CLR infers for each regulator only the most significant targets.
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