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Michael Hastings of KPMG talked about what he considered the single most significant systemic reason that entrepreneurship was not developing in Africa: very high interest rates.
This phenomenon is commonly referred to as 'Experiential Travel' and is arguably the most significant, systemic trend in global travel.
The implementation of primary health care (PHC) may well be one of the most significant systemic and ideological health reforms of modern times [ 1].
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Similar to results in previous studies, the most significant effect of systemic MSG administration was to increase blood pressure.
To date the most significant developments in the systemic treatment of breast cancer have been from therapies targeted against the ER and HER2.
Recently, the most significant advances in survival benefit from systemic therapy have come from moving the administration of therapy to an earlier disease state.
There are major disadvantages associated with systemic off-label bevacizumab therapy, the most significant of which is the possibility of life-threatening systemic AEs.
16– 18 In most of the studies with the DEX implant, no significant systemic adverse events (SAEs) were reported; 78, 106 however, most of these studies included a small sample size and were continued for less than 1 year.
The systemic nature of our most significant risks calls for procedures and institutions that are globally coordinated yet locally flexible.
The World Economic Forum has recognized the challenge of global local coordination in its most recent Global Risk Report: The systemic nature of our most significant risks calls for procedures and institutions that are globally coordinated yet locally flexible.
Martin Gruenberg, the chairman of the F.D.I.C., described the measure as perhaps "the most significant step we have taken to reduce the systemic risk posed by these large, complex banking organizations".
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