Sentence examples for most significant single from inspiring English sources

But perhaps the most significant single issue is class size, not social class.

The coming of the open office was the century's most significant single change in the field.

It was when Cook brought him on in place of Graeme Swann from the Finchale End for the 44th over that Bresnan made his most significant single impact.

Earlier this year in Shandong Province, in perhaps the most significant single display of discontent, dozens of village directors resigned en masse to protest their lack of power.

Perhaps the most significant single factor is the Syria crisis, which has continued to escalate and become more complex, involving numerous proxy powers.

The problems in Libby, a town of 2,700, represent the "most significant single source of asbestos exposure" in the nation's history, said Paul Peronard, a coordinator for the Environmental Protection Agency.

Aaliyah's "Are You That Somebody?" is among the most significant singles of the nineties: the beat refuses to fully engage, using more dead space than you would have thought possible in a hit.

The most significant single-nucleotide polymorphisms (SNPs) in the 15q13.1 locus (rs1129038 and rs12913832) lie within a genomic region that has profound effects on eye and skin color; notably, 50% of variability in eye color is associated with variation in the SNP rs12913832.

First, a gene-wide correction was applied to the most significant single-SNP p-value in each gene.

The first was based on the most significant single-SNP p-value and the second, 'set-based', analysis was based on the average chi-squared statistic of all SNPs in the gene, calculated under an allelic association model.

The latest hack was by far the most significant: the single AP tweet stunned investors and effectively wiped out $136.5 billion of the S&P 500 index's value in a matter of minutes.