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As the second most significant region identified in this study approaches significance and surrounds another Ca2+-regulated Ca2+-regulatedssociations between gene expression and SNP genotypes in both regions were investigated.
GISTIC assesses the significance of a 'new' region conditional on having found the previously most significant region(s) using a procedure the authors term the 'peel off' algorithm.
Additional in silico data provided replication of the findings from the most significant region on chromosome 1q21.3 rs7412746 (P = 6 × 10 -10 10 -10
The most significant region rich in SBRS2 was located at Gm9, where 1095 copies of the SBRS2 clustered in a 270-kb region.
The most significant region included SNPs H3GA0046827 and H3GA0046828 on SSC16, where no coding gene has been identified.
Because the segment belongs to the most significant region for host restriction, the host becomes very sensitive to residue details in S2.
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The most significant regions of alteration are amplifications on 8q and 17q and deletions on 17p and chromosome 10.
In Alpine, the 2 most significant regions were associated with chest depth on CHI 6 (45.8–46.0 Mb) and CHI 8 (80.7–81.1 Mb).
Indeed, MYC and MYCN loci comprise the most significant regions of amplification observed in Group 3 and Group 4, respectively (Fig. 3a, b, Supplementary Figs 13, 14, 17 20 and Supplementary Tables 12 15).
In the graphical view the most significant regions of this human gene coexpression network have been marked with background colors to enhance them as constellations within the coexpression landscape.
As expected, the most significant regions of copy number gain predicted by both GISTIC and overall frequency were located on 3q (63% of samples with CN gain) and 8q (62% samples with CN gain) (Figure 1).
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