Sentence examples for most significant problems from inspiring English sources

That immediately solves one of the most significant problems.

2) What are the three most significant problems?

The most significant problems of Mr. Ashcroft's tenure have been centered largely on the F.B.I.

The agency's most significant problems are mismanagement and a culture that is excessively risk-averse.

Coking is one of the most significant problems encountered in these processes.

SOME of the world's most significant problems never intrude upon headlines.

When these actions fail, the map has failed and this is the source of Apple's most significant problems.

Asia is seen as having the most significant problems, accounting for around 40% of all illicit outflows from developing countries.

One of the most significant problems is the "future dangerousness" standard adopted by the Texas death penalty statute.

In a way, these two poles seem to articulate one of the most significant problems that theatre faces.

From a public-health perspective, physical inactivity is one of the most significant problems of the twenty-first century.