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The most significant problem, says Filarowski, is consumer expectations for inexpensive clothing.
If Pettitte does start Tuesday, his inactivity will mean that sustaining adequate control will be his most significant problem.
The most significant problem concerns the acoustics at the Sitnik Theater, the 485-seat main stage of the Lackland Center.
"The social stigma of blindness is the most significant problem, not the loss of sight," wrote Dr. Buffa Hanse in The Braille Monitor.
"The single most significant problem we face," Mr. Cheney said, "is finding skilled, trained people to fill the jobs that are out there.
But the most significant problem the magazines face is that readers have increasingly turned to the Internet, where the pornography is often free.
Similar(12)
The most significant problems of Mr. Ashcroft's tenure have been centered largely on the F.B.I.
The agency's most significant problems are mismanagement and a culture that is excessively risk-averse.
SOME of the world's most significant problems never intrude upon headlines.
When these actions fail, the map has failed and this is the source of Apple's most significant problems.
Asia is seen as having the most significant problems, accounting for around 40% of all illicit outflows from developing countries.
More suggestions(15)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com