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We clearly show in a large cohort that there are no differences between these groups of patients, as the most significant probe had an adj P of 0.9998.
Tnfrsf9 is represented on the array by three probe sets (1460469_at, 1428034_a_at and 1421481_at) with '1460469_at' being shown in the results table as the most significant probe set of the three.
Since promoters sometimes involved more than one significant probe, in all comparisons with the gene expression data and correlations across generations, only the most significant probe of each promoter was considered.
Probe lists were collapsed to gene lists using a Python program based on the annotation files for the Human Genome U133 Plus 2.0 GeneChip provided by Affymetrix (Release 33), with the gene assumed to be represented by the most significant probe.
In order for expression to have been considered changed, a majority of the probe sets targeting the gene needed a Benjamini and Hochberg corrected FDR of less than 0.05 and the most significant probe required a fold change of at least 1.5-fold between KDM2B knockdown and scrambled control samples.
Similar(55)
In this analysis, we ranked the probes on significance and then selected 5% of the most significant probes that showed an at least three-fold change.
Levin has been behind one of the Senate's most significant probes, investigating how tactics from the C.I.A.'s SERE (Survival, Evasion, Resistance, Escape) program, which was established to train American troops in surviving capture and resisting torture by enemies who don't abide by the Geneva Conventions, were adopted by United States military interrogators in the war on terror.
Where multiple probe-sets existed for a gene we have reported the result for the most significant probe-set.
Adjusted p values are referred to using the notation q throughout and where multiple probe-sets exist for a gene the result for the most significant probe-set is reported.
Interestingly, the most significant probe-set is the only one which targets type IV with 100% coverage; further investigation by microarray or QPCR using isoform-specific probes is required to confirm expression of NRGI isoforms during adolescence.
Let Y be the 100 most significant probes in the UPPS+ cohort, as described below in the derivation of AP4.
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most prominent probe
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most variable probe
most damaging probe
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most significant alcohol
most suitable probe
most significant support
most significant painter
most significant shake-up
most significant triangulation
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most specific probe
most significant statement
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