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While enriched miRNA in exosomes of fusion-negative RMS cells were distinct from those of fusion-positive RMS cells, the most significant predicted disease and functions in both groups were related to processes relevant to cancer and tissue remodelling.
After the assignment of regulators we took a stringent cutoff corresponding to the top 2% most significant predicted regulatory interactions (Figure 1), obtaining a final set of 294 unique regulators (the complete list of module genes and regulators is available in table S1).
The most significant predicted change is a decrease in TAGs, consistent with previous data.
MEME identified 45 putative LexA-binding sites with an overall E-value of 1.4e-026 for its most significant predicted motif, while BioProspector detected 39 putative LexA boxes in its most significant predicted motif (see Additional file 1 for details).
To determine the most significant predicted genetic interactions with tau, all genes with P < 0.05 from all 35 networks were compiled together.
The first and most significant predicted function for the NPE not present in the CPE was "development of neuronal tissues and organs, including eye, retina, brain and forebrain".
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Komori et al found that sensory disturbance was the most significant predicting factor of a negative conservative treatment outcome of lumbar radiculopathy [ 26].
In the IDC group, IH micrometastases were correlated with recurrences (P = 0.01) and were the most significant predicting factor, but were less correlated with survival (median follow-up: 15.6 years).
The results of this study indicated that perceived benefits was the most significant predicting factor for physical activity among elderly regardless of number of falls, self-reported health and daily living activities.
Table 2 presents the statistical results for the comparison between the most significant values predicted by some combinations and the measured values for the cell temperature Tc.
Among the most significant processes predicted to be affected by all three drugs are interleukin-1 signaling, oncostatin M signaling, histamin H1 receptor signaling and macrophage migration inhibitory factor (MIF) signaling as well as transcriptional regulation through peroxisome proliferator-activated receptors (PPARs).
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