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Table 3 depicts the ten most significant pathways enriched by IPA in the ciliary body proteome.
Using a permutation test with 1000 times, the cutoff of significance level p value was set as 0.01 for the most significant pathways related to aging.
Additionally, the most significant pathways were neuronal differentiation, nervous system development, neurogenesis and regulation of cell differentiation (Supplementary Fig. 11b).
Among the most significant pathways was the death receptor apoptosis pathway (p<0.01).
This figure also shows the top 5 most significant pathways and diseases for the BMI -and insulin-associated proteins.
To focus on the most significant pathways, 5,000 SNPs with the most significant association (p<0.01) were used in this analysis.
Axon guidance was among the most significant pathways to be affected by the predicted target genes and was the top prediction for miR-9, miR-30 and miR-20.
Convincingly, out of 205 potential human pathways listed in the Kyoto Encyclopedia of Genes and Genomes (KEGG), four of the top seven most significant pathways from each approach were identical and meta-analysis demonstrated 10 pathways to be highly significant.
The 10 most significant pathways maps and toxicity networks are shown.
In A172 cells, the most significant pathways affected by hHSS1 overexpression were related to metabolism.
Thirty most significant pathways after enrichment analysis on differentially expressed genes.
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