Sentence examples for most significant obstacle from inspiring English sources

Viral latency remains the most significant obstacle to HIV eradication.

"That may rate as the most significant obstacle to getting the full complement of passengers back on the plane," he said.

The 54-year-old has hinted that he would be willing to talk with the SFA, but financial constraints represent the most significant obstacle to him succeeding McLeish.

Collins warned that lack of "interoperability" in medical record systems and gene databases could be the most significant obstacle to the NIH's plans.

For some researchers, the most significant obstacle to the successful replication of experiments is the outdated text format of traditional journals.

The most significant obstacle to the adoption of the framework is the industry commitment and the client's readiness to pay for additional services.

For Brown, senior year provided the most significant obstacles.

One of the most significant obstacles in combating sexual exploitation is the fact that most anti-trafficking campaigners see prostitution and sexual exploitation as one and the same.

The bias toward resolution and growth in families is strong once the most significant obstacles are removed, but it is never perfect.

The result has been flattering portrayals of President Vladimir V. Putin that are drawing comparisons to Soviet broadcasts and prompting warnings that the state's control over the airwaves has become one of the most significant obstacles to a democratic society.

A foundation year would seem to be a neat solution to the constant refrain of the Russell group that the effects of poverty and poor schooling are the most significant obstacles to widening participation.