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The phrase 'most significant number' is correct and usable in written English.
You can use it to refer to the most important or noteworthy number in a list of numbers or statistics. For example: "The most significant number in the report was the 3.4% decrease in sales from last year."
Exact(11)
Perhaps the most significant number Girardi could have worn in 2009 is 206,811,689, which represents the number of dollars the Yankees spent on compiling the biggest payroll in baseball.
The most significant number from yesterday's annual shopping bonanza, however, is not how much Chinese consumers spent, but what devices they used to make purchases from Alibaba's marketplaces.
"The most significant number of all?
But this change was not gradual: There was a marked increase in fires beginning in the 1990's, and so far, the 2010's have clocked the most significant number of fires compared with any decade since.
The district with the most significant number of cases was Salinas, followed by Sóco and Pantanal.
The MPH-AS with the most significant number of MPH-correlated genes (MPH-AS8.9) co-localizes with all three congruent QTL on chromosome 8.
Similar(49)
The most significant numbers are those given in the levels of comparison labeled 2 and 3, which represent the first and second stages, respectively, of the process of geographic speciation.
Sheffield, Bolton and Hull have received the most significant numbers, accounting for just under half of all refugees resettled under the programme between 2004 and 2012.
In order of importance, this is how I would rank them — number one being the most significant and number four the least: 4) Mitt Romney's big victory: As the results came in, Mitt's supporters were understandably keen to remind us that this is the first time a non-incumbent Republican candidate has been victorious in both Iowa and New Hampshire.
Perhaps most significant, a number of Silicon Valley venture capitalists are expanding into New York.
The loci with the most significant lower copy number in UMC-11 cells are in the chromosome 9 deletion, where the loci show copy number two in the female pool.
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com