Sentence examples for most significant methylation from inspiring English sources

The most significant methylation difference was found for SVOPL in three PHPneg patients.

Data from The Cancer Genome Atlas (TCGA) were used to verify the most significant methylation results.

In our analysis, we have selected the region with the most significant methylation change for each gene.

Furthermore, the most significant methylation changes that may be associated with pathogenic processes appear to be very stable over time in FLS lines.

When comparing the association results of the linear model described in this paper and the same model parameters applied to lmekin but with the addition of family structure, we found a great similarity in the distribution of p values, inflation factors, and even in the robustness in the most significant methylation sites in terms of both ranking and p values.

Most importantly, DOK7 showed the most significant DNA methylation changes in blood-based and primary breast cancer settings, suggesting that it could be useful as a novel biomarker for this tumor type.

This remains the trend for average weighted methylation levels [ 22] in genic regions (Fig.  4b), where the most significant differences in methylation levels were observed in promoter regions for CHH methylation.

Next, we used MS-HRM analyses to quantify PLA2R1 methylation at 5'-CpG sites identified with most significant differences in methylation between healthy control subjects and leukemic patients.

Stage II tumors showed the most significant difference in methylation levels when compared with DCIS and stage I and then in stage III and IV methylation levels were lower but still significantly higher than in DCIS and stage I.

The preponderance of most significant post hoc methylation findings were with the rs6265 G or Val homozygotes at CpG sites that were significant after FDR in the initial BD control analysis (D2, CpG unit 3; D3, CpG units 11,12,13; 11,12,13; 22,23,8).

A region of 7.7 kb drove the most significant haplotype-specific methylation, and overlies a region containing putative enhancer sequence.