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"I think this is the most significant issue," he said.
The most significant issue is the price tag.
Nothing's getting done on the most significant issue facing them".
The most significant issue is the Florida "Stand Your Ground" law.
The most significant issue to be resolved was how the electors themselves would be chosen.
For many Maori people, the most significant issue in New Zealand remains that of the land.
That relationship is probably the most significant issue at stake in these elections.
The most significant issue is the relation between hearing loss and dementia.
The result of the game, though, was never the most significant issue.
But decentralizing power represents potentially the most significant issue a new pope could address.
Stevens said the timing of a rate hike in the US is not the most significant issue.
More suggestions(15)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com