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The resistance in Slovakia is the most significant hurdle standing in the way of the deal.
The minefields of the Shamali plains, which lie north of Kabul, are perhaps the most significant hurdle.
Yet probably the most significant hurdle Google Glass now faces before popular adoption is its photo and video capabilities, which make some people uneasy and others upset.
The implementation of efficient strategies for cellular delivery is the most significant hurdle in the development of oligonucleotide and protein-based nanomedicines.
But a meeting with Afghan reporters demonstrated the popular opinion here that Pakistan remains the most significant hurdle to victory over the insurgency inside Afghanistan.
As the field of tissue engineering progresses ever-further toward realizing clinical implementation of tissue-engineered constructs for wound regeneration, perhaps the most significant hurdle remains the establishment of non-destructive means for real-time in vitro assessment.
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Sexual transmission remains one of the most significant hurdles in the fight against HIV infection.
One of the most significant hurdles scientists in the life sciences face in developing the next drug or device is raising capital.
His most significant hurdles will be applying for reinstatement and convincing Commissioner Roger Goodell that he is truly sorry for his crimes.
One of the most significant hurdles to the affordable, accessible delivery of cell therapy is the cost and difficulty of expanding cells to clinically relevant numbers.
These last two issues are the most significant hurdles (Mr Emanuel would like schools to be able to hire the best teachers, not the most recently-fired ones).
More suggestions(15)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com