Sentence examples for most significant difficulty from inspiring English sources
Given the prevalence of the negative stereotyping, it is perhaps not surprising that one of our main findings is that public unpopularity of enforcement is the most significant difficulty local authorities face, with two thirds (66.7%) of respondents stating this is a problem.
However, the most significant difficulty in dyslexia is the lack of identifying the patterns of dyslexia.
The family referred to the costs of care as the most significant difficulty.
The most significant difficulty we had lay in the fact that there is no agreed terminology used to label this kind of research endeavour, and so we aimed to develop a very wide and inclusive search strategy.
The most significant difficulty is the inability of these in vitro 3D models to fully mimic the defined in vivo 3D orientation, of either normal (i.e. polarity; distinct structural architecture) or aberrant (loss of structural integrity) epithelial cells, that dictates intracellular, intercellular and cell extracellular matrix (ECM) signaling [ 33].
One of the most significant difficulties with developing Service-Oriented Architecture (SOA) involves meeting its security challenges, since the responsibilities of SOA security are based on both the service providers and the consumers.
One of the most significant difficulties in establishing stable operation of the molecular diagnostics laboratory in Bo was inadequate power necessary to run laboratory equipment.
The loss of this ability is one of the most significant difficulties faced by individuals with hearing loss or damage to the auditory system, and may also be affected by the normal ageing process.
Among the most significant research difficulties in such networks safety is intrusion detection, whose target is to distinguish between misuse and abnormal behavior so as to ensure secure, reliable network operations and services.
The most significant is the difficulty in obtaining primary human cells and the tissues from which they are isolated.
But, at the same time, it poses some important problems, the most significant being the difficulty of field rotation and the build-up of pathogens.
