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FEV1 is regarded as the most significant correlate of survival in COPD and is used as a measure of disease severity in the staging of COPD.
Knowledge of the state language is by far the most significant correlate of the willingness to naturalise in Latvia.
Lower hippocampal activation during retrieval was the most significant correlate of clinical severity of memory loss in mild cognitive impairment (P <.001).
Second, a lack of proficiency in the state language (Latvian) – the single most significant correlate of the willingness to obtain citizenship – is another obstacle.
For DDE, age was invariably the most significant correlate.
The most significant correlate with PBB was quarantine status.
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To investigate whether the observed negative correlation between baseline and treatment induced changes are stable over time we measure the expression level of the most significant correlating gene (RSAD2; see Table 3) again after three and six months of IFNß therapy.
The negative correlation was maintained after three (R = −0.7363; p = 0.0027) and six (R = −0.8154; p = 0.0004) months of treatment, as determined by gene expression levels of the most significant correlating gene.
The analysis of the individual discriminatory situations revealed many similar associations, with level of education, and wealth being the most significant correlates regardless of the discriminatory situation itself.
The decrease in WBC and ANC was most significant correlated with the dose (D) of MAG-CPT and this relation was best fit to a sigmoidal Emax model (parameters: Emax=53.3%; D50=140 mg; γ=7.4, and Emax=100%; D50=123 mg; γ=5.6 for WBC and ANC, respectively).
GO-term analysis of Biocarta gene set pathways revealed that the top ten most significant correlations were all negatively correlated to cell cycle regulation, chromosome function, recombination and replication (Fig. 6b).
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