Exact(3)
Whereas a number of studies consider subaerial processes as the dominant processes, fluvial erosion was found to be the most significant causal process, and in particular the mean discharge of floods.
The paper outlined what the most significant causal factors were for this exaggerated level of violence by developing what was called "an ecological theory of crime".
The most significant causal edges between regulators are then used to construct networks downstream of a 'master' regulator in order to indicate possible causal (e.g. signaling) mechanisms.
Similar(56)
Overall, the results from the SEM and LLM approaches were comparable; the most important significant causal relationships among those caregiver relevant factors in the path model corresponded to significant associations between the same factors in the LLM.
Secondly, although the relationship between disability and poverty needs more research, especially to determine the most important causal factors [ 30], poor physical functioning may be a significant element that acts as a mediator in this association.
The two most significant challenges to establishing a causal pathway between (human) parental DU exposure and the birth of offspring with defects are: i) distinguishing the role of DU from that of exposure to other potential teratogens; ii) documentation on the individual level of extent of parental DU exposure.
Analyses for all SNPs were repeated adjusting for the most significant SNP to assess whether multiple independent causal variants were present (i.e. a forward stepwise regression approach).
Due to the complex LD structure, the most significant SNP is usually not the true causal locus but just a marker for the true locus, which would typically be within 20 kb.
More interestingly, 4 out of 10 most significant Markov relations have already been reported to be causal in literature.
The same was true for the lesioning phenotype, where the most significant interval was found just upstream of the known causal gene ACCELERATED CELL DEATH (ACD6) (Todesco et al., 2010).
SNPs with a likelihood ratio of ≥1/1000 relative to the most significant SNP describing each signal were selected as potential candidate causal variants (45).
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