Sentence examples for most significant candidate from inspiring English sources

We found that the most significant candidate locus under positive selection in Tibetan-contained pairs was the region containing EPAS1 (HIF-2α) (P<0.001 in all population pairs with Tibetans).

We utilized the RNAi methodology to investigate the selenium response under reduced expression levels of KCNMA1 (the most significant candidate) in PC3 as well as in LNCaP cell lines.

Using the RNAi technology, we have investigated the response of PC3 and LNCaP cell lines to selenium treatment in the presence of low expression levels of KCNMA1, the most significant candidate gene discovered in the present study.

We identified ZNF703 as the most significant candidate oncogene of this amplification.

The initial model included all SNPs and age as main effects, and then searched for the most significant candidate interactions to enter into the model based on the score statistics at the 5% level.

We then genotyped 874 Caucasian lung cancer patients (76 SCLC and 798 NSCLC) for the 170 most significant candidate SNPs identified during the association studies with the 276 LCLs.

However, while the statistics to identify the most significant candidates are well defined in GWAS from individual samples, there is no widespread agreement on which analysis pipeline should be used to prioritize SNPs for individual genotyping in pooled GWAS.

To judge the most significant candidates and investigate the cellular function, the signaling pathway and GOs of these target genes were analyzed.

Based on these results, the miRNAs which were involved in both signal transduction and the regulation of actin cytoskeleton or pathway in cancer might be the most significant candidates.

To narrow down the scope of study and judge the most significant candidates, the intersection of signal transduction and regulation of actin cytoskeleton and pathway in cancer was selected for follow-up study.

The most significant candidates were selected and in vitro functionally evaluated in four epithelial ovarian cancer cell lines (SKOV-3-, CAOV-3, ES-2 and OVCAR-3), using gene silencing combined with drug treatment in viability and apoptosis assays.