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The project appears to be the most significant attempt to challenge the main parties yet to emerge.
It's the company's most significant attempt to fix issues that may have led to two recent catastrophic crashes.
This proposed rulemaking is the most significant attempt to overhaul the federal regulations governing the conduct of clinical research involving human subjects since the regulations, known as the Common Rule, were promulgated in 1991.
The most significant attempt came in 1904 when MIT President Henry S. Pritchett and Harvard University President Charles W. Eliot attempted to negotiate a merger between their respective institutions, despite rampant resistance from MIT alumni and faculty.
If Tazara represented the first and most significant attempt to forge a lasting south-south engagement, it remained for almost three decades an isolated and anomalous project, its lustre fading as soon as the inaugural trip had been undertaken.
It is shown that accounting featured prominently, at diverse levels of government, in what has been identified as the most significant attempt to address rural poverty in American history.
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He has bluntly advanced it in his criticism as one of the most significant attempts to find a new music for our time.
The survey, one of the most significant attempts to gauge the public mood about fairness and inequality under the coalition, found significant support for statutory maximum pay ratios to prevent company executives earning more than 65 times the salary of the lowest-paid employee in their company.
It will analyze some of the most significant attempts to think such a trauma made by German-Jewish exiles (Arendt, Adorno, Anders), the survivors of the Nazi camps (Améry, Levi, Celan, Antelme), as well as the public intellectuals on both sides of the Atlantic Ocean (Sartre, Bataille, MacDonald, etc).
The Rosneft deal would also be among the most significant attempts by a company from a country that is not an American ally to acquire United States oil fields since Cnooc, the large Chinese oil company, tried to buy the California oil company Unocal.
The $756,000 initiative marks one of the county's most significant attempts to find a better way to treat people who have mental illness and wind up in the criminal justice system by offering them transitional housing, medical treatment and job-hunting help.
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