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Based on this probability ranking only the top 50 statistically most significant annotation terms are reported.
For the labels of the FGs in Figure 3, the most significant annotation term within each FG was chosen (see Table S2, S3).
These are the most significant protein interactions found for upregulated genes, and the most significant annotation of this group is "DNA-repair" and "response to DNA damage stimulus".
For gC, 'synaptic depression' remained the most significant annotation.
The next most significant annotation is "organic acid transport" with four genes.
The most significant annotation enrichment in pattern I gene list is "mitochondrion".
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Remarkably, the three most significant annotations are related to transcriptional regulation, with a total of 10 genes annotated as having transcriptional regulator activity.
As expected, the differential genes were indicative of the proneural subtype, with some of the most significant annotations including Differentiation of Astrocytes, Neurogenesis, Cell Death, Development of Blood Vessels, and Benign Tumor (Table S10).
The most significant annotations for gF in this analysis fell under the disease and disorder category of 'Cardiovascular Disease' (e.g. 'vascular disease', FET P = 7.1 × 10−6; Dataset S3).
The most significant annotations enriched for trait-associated SNPs were open higher order chromatin domains, eQTLs, DNase clusters, and exonic regions.
Among the most significant annotations (P < E-100) are for snake toxins, secreted proteins (based on annotation of signal peptides), Phospholipase A2, Knottin, protease inhibitor and defensin (ranges at E-70 E-60 E-70 E-60 E-70 E-60
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