Sentence examples for most significant alteration from inspiring English sources

The most significant alteration is the nearly complete removal of the fourth and final novel in the series, "Last Post," which is the most abstract, the most difficult and maddening, and contains the least amount of action (the main character, Tietjens, appears hardly at all).

The gearbox is the most significant alteration, because upshifts are now 60 per cent faster and downshifts are 50 per cent quicker, making the dual clutch gearbox more pleasant to use.

In the 1690s, Nicodemus Tessin designed a new burial chapel to the east of the south transept, the most significant alteration to the plan of the cathedral since the Middle Ages.

The most significant alteration after QKI silencing was the decreased expression of genes involved in interferon (IFN) induction (P = 6.3E-10), IFIT1dIFIT2FIT1, IFIT2, MX1, MX2, G1P2, G1P3, GBP1 and IFIH1.

The hippocampi of AD brains showed the most significant alteration in gene expression profile.

25 However, low HDL was the most significant alteration (31.57+0.83 mg/dL), a fact that was not observed here.

It's been suggested that the erection of this vast hydroelectric plant is among the most significant alterations ever made to the natural world.

Mr. Ailes's renewal comes at an important time for Fox News, as it adjusts to the coming Democratic administration in Washington and introduces two evening programs, making the most significant alterations to its schedule in six years.

European cultural landscapes have been subject to change since the middle of the twentieth century, and among the most significant alterations are general re-growth, reforestation, and overgrowth.

Among Wright's most significant alterations was the addition of white marble with Persian-style ornamentation.

Interestingly, some of the most significant alterations in this group of genes were found to involve genes of complex I of the respiratory chain (NDUFA10, NDUFA6, NDUFB10, NDUFC1, NDUFS5).