While all BAVs increased WSS unidirectionality on the proximal AA relative to the TAV, the most significant abnormality was achieved by the BAV with left-right-coronary cusp fusion on the wall convexity (up to 0.26 decrease in oscillatory shear index vs. TAV).
In our study, we discovered that in the absence of 12p gain the most significant abnormality is loss of 16p (P=0.04), irrespective of histology.
However, a study of oxaliplatin-induced neurotoxicity in humans showed that the most significant abnormality in the nerve conduction study results was a low-amplitude sensory nerve action potential (SNAP) in all eight symptomatic subjects.
Radiological studies do not come with inbuilt labels denoting the most significant abnormalities, and interpreting them is not a binary process (normal vs abnormal, cancer vs "all-clear").
Very high-frequency signals, 1000 2884 Hz, revealed the most significant abnormalities underlying chronic migraine in terms of in the contour map patterns and the aberrant regions of activation revealed by magnetic source imaging.
The most significant abnormalities involved delay of the relaxation process, slow relaxation ratio and delay in peak ratio of isometric and isotonic relaxation.
Radiological studies do not come with in-built labels denoting the most-significant abnormalities, and interpretation of them is rarely a binary process (normal vs. abnormal, cancer vs. "all clear") [1].
In accurately identifying the final cause of death or most clinically significant abnormality, post-mortem MR imaging had a sensitivity and specificity of 69%95%5% CI 56%, 80 % and 95%95%5% CI 88%, 98%) in fetuses, and 28%95%CI 13%13%, 47%) and 64%95%CI 23%23%, 94%) in children and adults, respectively; however the published data is limited to small, heterogenous and poorly designed studies.
Patients were grouped according to the most significant grade of abnormality found giving five different outcome groups: cancer, advanced adenomas, adenomas of size 6 to 9 mm, adenomas of size ≤ 5 mm, and no cancer or any adenomas.
The 100 1000 Hz range also revealed the most significant spectral power abnormalities of chronic migraine in the global spectrograms.
The multivariable analyses identified 7q abnormalities as the most significant of the cytogenetic abnormalities, with impact on survival beyond that of age and PS.
