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The logical framework conveniently supports the qualitative nature of current knowledge of most signalling and regulatory mechanisms.
In homogeneous assays (e.g., by Western blot), the total levels of active RTKs can be observed to rapidly decay with time in most signalling systems (Dunn and Hubbard, 1984; Burke et al., 2001; Sousa et al., 2012).
We believe that this is due to the amplification of the receptor signal seen by most signalling cascades (Mayawala et al, 2004).
The interplay of 518 human kinases and the phosphatase family creates a signalling network that controls most signalling processes through reversible phosphorylation [1].
Rather than assume (as most signalling models do) that there are just two classes of people above and below average the authors start with three categories: high, medium and low ability.
Most signalling by the Met receptor is mediated by two C-terminal tyrosines, referred to as multifunctional docking sites.
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Most signaling molecules studied today are proteins, after all.
Most signaling networks function in a highly non-linear and often contextual manner.
The residual interference due to imperfect CSI will increase until offset most signal gain.
Most signaling proteins have modular structure, formed by various combinations of a limited number of conserved protein domains.
However, this approach is very limited as most signaling pathways do not end with cell death.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com