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The major acute toxic effects of chemotherapy (⩾grade 3) represent the most severe toxicity associated with the study treatment for each patient (Table 3).
Neutropenia was the most severe toxicity noted in this study.
Modifications were to be made based on the most severe toxicity.
Based on the most severe toxicity experienced since the last treatment, the scheduled treatment rest period should be extended until all toxicities subside to grade 1 or less.
The most severe toxicity was cardiovascular: six episodes of hypotension occurred in five patients who had been treated with doses ranging from 3.0 to 4.7 mg m−2 h−1.
Similar(55)
As expected, the most severe toxicities were primarily hematologic and hepatic.
Despite the absence of details, most severe toxicities were presented in each trial and therefore worst toxicity meta-analysis was feasible.
Associated side effects are reported in Table 4. Haematological toxicity was the most frequent severe toxicity.
The most frequent severe toxicity was asthenia (15% of patients), diarrhoea and stomatitis (8% of patients, each).
The most common severe toxicities were proteinuria (11.4%) and hypertension (8.5%).
The most common severe toxicities included rash (13%), diarrhea (13%) and hypertension (8%).
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