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The reason why subjects with the most severe systemic reactions did not develop severe local reactions is not known.
The most severe systemic reactions occurred in the 4 mg dose group and after the second immunization.
Loxosceles is the most poisonous spider in Brazil and children, who develop the most severe systemic effects after envenomation, nearly always die.
In recent years, however, the early use of steroid therapy has become progressively established in a wide range of infective conditions [ 1, 2], including septic shock, its most severe systemic manifestation.
Fibrosis is one of the most severe systemic diseases and is characterized by excessive accumulation of fibrous connective tissues, such as collagen, induced by acute or chronic injury [ 1].
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Current guidelines for asthma treatment recommend first-line anti-inflammatory therapy with inhaled and, in the most severe cases, systemic corticosteroids that are effective at controlling allergic airway inflammation in most cases; however, they also pose a significant risk for adverse effects, such as general or local immune suppression, diabetes, and adiposity [ 7].
Acute disseminated candidosis is the most severe form of systemic Candida infection in neutropenic patients.
See related research by Singh et al., http://arthritis-research.com/content/14/4/R164 Lupus nephritis (LN) is one of the most severe forms of systemic lupus erythematosus (SLE).
Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE), which is associated with significant morbidity and mortality of SLE patients.
The necessity of treatment is controversial in neonatal CMV infection, as spontaneous recovery is expected in most cases unless severe systemic disease occurs [ 3, 12].
Reactive systemic AA amyloidosis is one of the most severe complications of several chronic rheumatic disorders [42].
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