Laryngeal penetration-aspiration, the entry of material into the airways, is considered the most severe subtype of dysphagia and is common among patients with acute cervical spinal cord injury (SCI).
USH1 is the most severe subtype and USH1 patients suffer from severe hearing impairment, balance defects, and prepubertal-onset of retinitis pigmentosa.
USH1, the most severe subtype, is associated with mutations in genes encoding myosin VIIa, harmonin, cadherin 23, protocadherin 15, and sans.
Overall, the results show that associations are more quantitative than qualitative in that all treatment types are significantly less prescribed to less severe patients (i.e., patients subtype 1) and more prescribed to the most severe (patients subtype 3).
Harlequin ichthyosis is the most severe ichthyosis subtype.
The impairment was most severe for the subtype with symptoms of ADHD-C (combined) and less severe for the subtypes with symptoms of ADHD-PI (predominantly inattentive) and ADHD-HI (predominantly hyperactive/impulsive).
For both boy and girl adolescents, only those in the most severe hazardous adversity subtype (consisting of 6% of the sample) in the preschool years had any marked degree of influence on the level of depressive symptoms at the age of 14.
RDEB, generalized severe is the most severe of all DEB subtypes, because it is caused by absence or marked reduction of type VII collagen expression.
Glioblastomas belong to the most frequent and severe subtype of gliomas, and are one of the most aggressive human cancers, as demonstrated by the associated high mortality rate.
USH1 is the most severe of the three clinical subtypes, with profound congenital deafness and onset of vision loss usually before age 10.
