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The most severe side effects of hormone therapy are hot flashes, weight gain and reduced sexual desire.
Nevertheless, acetate megestrol was responsible for the most severe side effects.
Lipoatrophy is permanent and is perhaps the most severe side effect.
The most severe side effect was the development of pneumonitis, which caused three drug-related deaths.
In addition, one of the most severe side effects of MTX treatment is the development of hepatic fibrosis [ 30, 31].
Dexamethasone (Dex -induced osteoporosis has been Dex -induced the mosteoporosiside effect in long-term glucocorticoid thasapy.
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Seizures, one of the most severe side-effects, occur in less than 0.1% of users [ 4], whilst one in every two smokers will die prematurely if they continue to smoke [ 39].
36 ADRs resulting in admission, however, represent the most severe adverse side effects of medication use and lead to considerable morbidity and financial costs.
Mucositis was the most common severe side effect: 11% of patients in the bolus part and 2% in the CI part experienced grade III IV.
Because prolongation of QT interval is one of the most common severe side effects of both cardiac and non-cardiac drugs, new drug candidates must be carefully tested for their effects on the hERG channel.
Unexpectedly, the most frequent and severe side effect associated with trazodone in our sample was tachycardia, which was reported by 14 (21.2%) patients.
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