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In February 2006, Dr. Rosemary Johann-Liang, a drug safety supervisor, recommended that the labels of both Avandia and Actos receive the agency's most severe safety warning — called a "black box" — for their tendencies to worsen the risks of heart failure, a problem distinct from the heart attack risks seen only in Avandia.
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On Aug. 1, the Nuclear Regulatory Commission determined in a preliminary decision that a potential clogging problem at FirstEnergy's Davis-Besse nuclear plant merited the agency's second-most severe safety rating.
Marshals were waving double yellow caution flags - the most severe warning before a safety car is introduced.
The World Health Organization (WHO) recommendation to do so with eight weekly doses of 45 mg primaquine base does not come with evidence of safety among the most severe G6PD deficiency variants, which happen to be most common where P. vivax occurs in greatest abundance (south and southeast Asia).
Alcohol-impaired driving has been one of the most severe and long-lasting problems of road safety throughout the world.
One of the most crucial issues for the design of such applications is the heat convection required to ensure the safety of the device subjected to the most severe temperature under operation.
My foundation has been working to improve road safety in countries where the problem is most severe, including India, by decreasing drinking and driving, improving dangerous roads, strengthening enforcement of traffic laws, and promoting mass transit.
Judge Welsch, who had reduced the OSHA violation in the death of Brancheau from "willful" -- the most severe level -- to "serious," nonetheless upheld all of the safety abatements imposed by OSHA.
"By reserving the most severe penalties for serious, high-level or violent drug traffickers, we can better promote public safety, deterrence and rehabilitation, while making our expenditures smarter and more productive," he said.
Six months later, OSHA slapped SeaWorld with the most severe violation of all -- a "willful" one -- and ordered the park to install safety abatements that provide trainers with equal or greater protection than simply banning them from what is known as "water work" with orcas.
Congenital abnormalities represent perhaps the most severe side effects a chemical can have, and their prevention is an essential goal in toxicological safety assessment of chemicals and drugs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com