Antibody deficiency may be either primary or secondary, and the most common severe primary antibody deficiency (PAD) is common variable immunodeficiency (CVID), which accounts for the majority (57%) of all symptomatic primary immunodeficiency (PID) cases on the European Society for Immunodeficiencies (ESID) registry (http://www.esid.org).org
Cluster headache (CH) is the most common form of TAC and one of the most severe forms of primary headache [2 4].
The grade of school correspondingly plays a more important role; that is, the educational selection of the low social class is the most severe at the primary education stage.
Glioblastoma multiforme (GBM, also known as Grade IV glioma) is the most common and most severe form of primary brain cancer, with well-documented molecular heterogeneity and rapid fatality [1] [7].
SCID is the most severe form of primary immunodeficiency.
It is one of the most severe forms of primary immunodeficiency (PID), which is life-threatening when recognized too late.
Severe combined immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency characterized by absence of functional T lymphocytes.
SCID is one of the most severe forms of primary immunodeficiency and is a paediatric emergency, which is life-threatening if recognized too late.
Indeed, Deegens et al. [ 12] analyzed the differences in foot process width between patients with primary versus secondary FSGS and found the effacement to be most severe in cases of primary FSGS, with foot process relatively preserved in secondary cases, with little overlap between the two.
Although it is clear that most severe disease occurs during primary infantile infection, symptomatic upper respiratory tract infections occur throughout life.
