While many patients benefit from pain killers, there is growing evidence from studies, including one in Washington State, that others suffer significant side effects, including lethargy, increased sensitivity to pain and, in the most severe instances, potentially fatal overdoses.
This leads to formation of ~50 "endogenous DSBs", the most severe and potentially mutagenic lesions [ 6].
In humans, it can cause flulike symptoms, or at its most severe phase, encephalitis, a potentially fatal swelling of the brain.
Or prioritize the potentially most severe ones?
[20], [46] Thus, while death of the most severe patients could have potentially influenced the outcome of this study because of the extremes of phenotype design, we do not believe that limitation is a critical factor in the findings reported here.
At their most severe, cSSSIs can include potentially limb- or life-threatening infections such as necrotizing fasciitis.
This is especially so, since the genes expressed in the final larval stage of chironomids should be particularly prone to increased diversifying selection compared to the rest of the genome, because this is the phase in the life of the midges during which the competition (e.g. for space and food) is potentially most severe among species [ 61].
As Michael's eyewall continues to collapse, the most severe winds will weaken, but potentially damaging winds will still impact southwest and southwest Georgia.
However, these impacts have seldom been quantified at a regional level, particularly in arid and semi-arid systems where the gap in knowledge is the greatest, and impacts potentially the most severe.
As Pipes puts it at his most alarming hyperbolic best: "The arrest and indictment of top military figures in Turkey last week precipitated potentially the most severe crisis since Atatürk founded the republic in 1923.
