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This represents the most severe disruption to the network since 2002, and people using the service can expect delays.
The most severe disruption to the bridge was caused between 1996 and 1999 when it was closed for repairs and strengthening.
The entire London Underground network is due to be shut down by this week's strike, the most severe disruption to the tube network since 2002.
The most severe disruption disease in one investigated cave is on its west wall and the other two walls close to the west wall, but disruption on its east wall is slight.
The most severe disruption is seen with a loss of either Cdon or Boc in the absence of Gas1; however, Cdon −/−; Boc −/− embryos also have more severe defects than are seen in any single mutants (Allen et al., 2011; Allen et al., 2007).
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Notch1, Dll4 and CSL mutations result in the most severe vascular disruptions.
The hurricane caused severe disruption in most of Nicaragua's remaining rain forests in the areas it hit, and also stripped trees of leaves.
Further assessment of various disease risk factors and their associated cognitive effects may lead to better identification of those children most at-risk for more severe disruption.
In this model the most severe phenotype showed widespread cortical disruption but the basal cortex was spared.
While people on both sides of the debate expect some upheaval in Louisiana if a health care bill is passed, Sheila Webb, a former city health director for New Orleans, pointed out that Louisiana is more experienced than most states in facing sudden and severe disruption.
However, we cannot conclude that the era of endocrine disruption in cricket frogs has come to an end, because in areas with the most severe decline in populations and most severe endocrine disruption historically, numbers of remaining cricket frogs are now insufficient to permit sampling.
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