The Political Violence and State Repression project capitalizes on the recent availability of unusually detailed and highly classified internal investigation reports compiled by the government of a province that experienced some of the most severe disorders and highest death tolls.
While an estimated one-quarter of people in this country suffer from some form of mental illness, it is a much smaller percentage of Americans who battle the most severe disorders.
In highly proliferative tissues, this effect would be greatly exaggerated and these tissues would be expected to show the most severe disorders, hence the prevalence of pathologies in the bone marrow, gut and skin.
Although this is the most severe disorder of the autism spectrum, it constitutes only a part of autistic spectrum disorders; specifically children with Asperger's syndrome and other pervasive development disorders were not studied.
Since patients with multiple FNS showed more psychological strain and reported more ACE in most domains (including sexual abuse), conversion disorder (F44.7) can be considered the most severe disorder of those under investigation here.
However, the most severe disorder is lethal acantholytic epidermolyis bullosa, which is caused by C-terminally truncated desmoplakin and was fatal in a 10-day-old hair and nailless newborn due to extensive blistering leading to transcutaneous fluid loss (Jonkman et al. 2005).
ISRCTN11889976 Psychotic disorders including schizophrenia spectrum and affective psychosis are considered among the most severe mental disorders [ 1], resulting in personal and family suffering [ 2, 3] and associated with poor long term outcomes, particularly if not adequately treated [ 4- 6].
Duchenne muscular dystrophy (DMD), one of the most severe neuromuscular disorders of childhood, is caused by the absence of a functional dystrophin.
However, it is more common for the electrode to be inserted into the subthalamus or the globus pallidus in Parkinson patients, since aberrant neuronal signaling in these areas gives rise to the most severe movement disorders associated with the disease.
These types of cells, if produced in sufficient quantities, could generate therapies to repair spinal cord injuries, counteract traumatic brain injury or cure some of the most severe degenerative disorders of the nervous system, like Parkinson's and Huntington's diseases.
Myotubular myopathy (MTM) is one of the most severe neuromuscular disorders of childhood, typically presenting at or around the time of birth with profound hypotonia, severe extremity weakness, progressive ophthalmoparesis, and, often, respiratory failure.
